Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Histamine H3 Receptor Antibody (D-5) is a high quality monoclonal Histamine H3 Receptor antibody (also designated Histamine H3 Receptor antibody) suitable for the detection of the Histamine H3 Receptor protein of mouse, rat and human origin. Histamine H3 Receptor Antibody (D-5) is available as the non-conjugated anti-Histamine H3 Receptor antibody. Histamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the central nervous, gastrointestinal, respiratory and immune systems. The effects of histamine are mediated by a family of G protein coupled receptors, the histamine H1, H2, H3 and H4 receptors. The gene encoding the human histamine H3 receptor is located on chromosome 20 and is expressed as six alternative splice variants in thalamus. These isoforms contain either a deletion in the second transmembrane domain or a variable deletion in the third intracellular loop. The existence of multiple H3 receptor isoforms suggests that H3-mediated effects may be regulated through alternative splicing mechanisms. The H3 receptor acts as an autoreceptor in the central nervous system (CNS) and modulates histamine synthesis and release. It also acts as a heteroreceptor in the CNS and cardiovascular, gastrointestinal and respiratory systems to regulate the release of a variety of neurotransmitters. The histamine H3 receptor responds to several agonists and antagonists, which make it a potential therapeutic target for several diseases, such as asthma, epilepsy and cardiac ischemia.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.