Histamine, free base (CAS 51-45-6)

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Alternate Names: 1H-Imidazole-4-ethanamine; Ergotidine; 2-(4-Imidazolyl)ethylamine

Application: Histamine, free base is a compound that activates NOS which results in the release of NO

CAS Number: 51-45-6

Purity: ≥97%

Molecular Weight: 111.15

Molecular Formula: C₅H₉N₃

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Histamine, free base is a potent vasodilator found in normal tissues and blood. This compound is formed by the decarboxylation of L-histidine and activates NOS (nitric oxide synthase), resulting in the release of nitric oxide. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization; whereas, histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H₂ receptor activation.

References

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178. Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477. Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952. Yan, Q.Z., et al. 1994. Agents Actions 41, C111. Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109. Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

Physical State :

Solid

Solubility :

Soluble in water, alcohol, and hot chloroform.

Storage :

Store at 4° C

Melting Point :

83-84° C

Boiling Point :

167° C at 0.8 mmHg

Density :

~1.1 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.57 (Predicted)

IC50 :

Histamine H1 receptor: IC₅₀ = ~1 µM (human)

Ki Data :

Histamine H3 receptor: K_i= 5.2 nM (human); Histamine H4 Receptor: K_i= 7.94 nM (human)

pK Values :

pK_b: 9.26 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

MS1050000

PubChem CID :

774

Merck Index :

14: 4719

MDL Number :

MFCD00005210

EC Number :

200-100-6

Beilstein Registry :

2012

SMILES :

C1=C(NC=N1)CCN

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Certificate of Analysis

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Histamine, free base (CAS 51-45-6) Product Citations

See how others have used Histamine, free base (CAS 51-45-6). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 11880261 Fischer, H. et al. 2002. Am. J. Physiol., Cell Physiol. 282: C736-C743.

PMID: # 8475118 Sudweeks, JD. et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 3700-3704.

PMID: # 4549916 Sofia, RD. et al. 1974. Life Sci. 15: 251-260.

Citations 1 to 6 of 6 total

Hi, we are looking for high purity of histamine. Could you please share with us your purification method as reference as well as the characterization method to determine the purity? Thanks!

Asked by: sunny66

Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.

Answered by: Technical Support

Date published: 2017-05-30

Rated 4 out of 5 by Anonymous from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.

Date published: 2015-04-20

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