HHIPL1 Antibody (H-11): sc-515618

HHIPL1 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects HHIPL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-HHIPL1 antibody (H-11) is available as the non-conjugated monoclonal isotype antibody. HHIPL1, also known as hedgehog-interacting protein-like protein 1, plays a significant role in regulating Hedgehog signaling, which is crucial for proper growth and tissue patterning during embryonic development. Located in the extracellular space, HHIPL1 interacts with Hedgehog proteins, including Sonic hedgehog, to modulate their activity. This interaction helps fine-tune signaling pathways that govern cell proliferation and differentiation, ensuring tissues develop correctly. HHIPL1 can bind to Hedgehog proteins and inhibit their signaling, which is essential for maintaining the balance of cellular processes during development and in adult tissues. HHIPL1 consists of 782 amino acids and features a distinct HHIP domain, with two isoforms generated through alternative splicing, highlighting its complexity and potential regulatory roles in various biological contexts.

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HHIPL1 Antibody (H-11) References:

1. Comparative genomics on HHIP family orthologs.  |  Katoh, Y. and Katoh, M. 2006. Int J Mol Med. 17: 391-5. PMID: 16391842
2. Blocking the hedgehog pathway inhibits hepatoblastoma growth.  |  Eichenmüller, M., et al. 2009. Hepatology. 49: 482-90. PMID: 19177589
3. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.  |  Bosanac, I., et al. 2009. Nat Struct Mol Biol. 16: 691-7. PMID: 19561609
4. Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.  |  Bishop, B., et al. 2009. Nat Struct Mol Biol. 16: 698-703. PMID: 19561611
5. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.  |  Choi, SS., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 297: G1093-106. PMID: 19815628
6. Interactions between Hedgehog proteins and their binding partners come into view.  |  Beachy, PA., et al. 2010. Genes Dev. 24: 2001-12. PMID: 20844013
7. Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples.  |  Shahi, MH., et al. 2011. J Neurooncol. 103: 287-96. PMID: 20853133

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HHIPL1 Antibody (H-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HHIPL1 Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HHIPL1 Antibody (H-11) Specifications

Alternate Product Name: HHIPL1

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 549-568

Epitope Target: HHIPL1

Epitope Species: human

Product Reactivity/Detection: HHIPL1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HHIPL1 Antibody (H-11): P: Blocking Peptide