Hh Signaling Antagonist VII, JK184An Hh pathway blocker and ADH inhibitor

Hh Signaling Antagonist VII, JK184 (CAS 315703-52-7)

Hh Signaling Antagonist VII, JK184 | CAS 315703-52-7 is rated 5.0 out of 5 by 1.
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Synonym: N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
Application: An Hh pathway blocker and ADH inhibitor
CAS Number: 315703-52-7
Purity: ≥98%
Molecular Weight: 350.44
Molecular Formula: C19H18N4OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hh Signaling Antagonist VII, JK184 is an imidazopyridine compound that inhibits the Hedgehog (Hh) signaling pathway. JK184 is described to directly interact with tubulin subunits and prevent their polymerization into filaments, affecting the Hh pathway by destabilizing microtubules and modulating the microtubule-dependent mechanisms regulating function of the Gli transcription factors. JK184 also inhibits ADH7 (alcohol dehydrogenase 7), a function suggested to be ancillary to the effects of JK184 on microtubules and the Hh pathway.


References

1. Lee, Jongkook., et al., 2007. A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem : a European journal of chemical biology. 8(16): 1916-9. PMID: 17886323
2. Cupido, Tommaso., et al., 2009. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angewandte Chemie (International ed. in English). 48(13): 2321-4. PMID: 19222062

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), methanol, and ethanol (25 mM).
Storage :
Store at -20° C
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
enzymatic activity of Adh7: IC50 = 210 nM; Hg-Ag-induced Gli-transcription activity : IC50 = 30 nM; sonic hedgehog induced Gli transcription: IC50 = 30 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1069686
SMILES :
CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C

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Certificate of Analysis

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Rated 5 out of 5 by from Cupido et al Cupido et al. (PubMed ID 19222062) found that Hh Signaling Antagonist VII, JK184 inhibited the Hedgehog signaling pathway in embryonic cells. -SCBT Publication Review
Date published: 2015-05-13
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