Herbimycin A CAS: 70563-58-5
MF: C30H42N2O9
MW: 574.66
An inhibitor of c-Abl, HSP 90, c-Src, c-Yes, Fes, and Ros.

Herbimycin A (CAS 70563-58-5)

Herbimycin A | CAS 70563-58-5 is rated 5.0 out of 5 by 1.
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Application: Herbimycin A is an inhibitor of c-Abl, HSP 90, c-Src, c-Yes, Fes, and Ros
CAS Number: 70563-58-5
Purity: ≥98%
Molecular Weight: 574.66
Molecular Formula: C30H42N2O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Herbimycin A, a benzoquinoid ansamycin antibiotic, is produced by the actinomycetes organism Streptomyces hygroscopicus and has antiparasite and antineoplastic properties. Herbimycin A irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups. Herbimycin A inhibits c-Abl, HSP 90, c-Src, c-Yes (Yes), Fes (Fps), Ros, and EGFR (ErbB) oncogene products and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C. Herbimycin A also inhibits platelet derived growth factor induced phospholipase D activation. Herbimycin A is an angiogenesis inhibitor and has potent herbicidal activity against most mono- and di-cotyledenous plants, especially against Cyperus microiria STEUD. Oryza sativa shows strong resistance to herbimycin.


References

1. Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42: 1661-1671. PMID: 1656993
2. Uehara, Y. and Fukazawa, H. 1991. Meth. Enzymol. 20: 370-379. PMID: 1658554
3. Satoh, T., et al. 1992. J. Biol. Chem. 267: 2537-2541. PMID: 1733950
4. Weiss, R.H. and Nuccitelli, R. 1992. J. Biol. Chem. 267: 5608-5613. PMID: 1544934

Physical State :
Solid
Solubility :
Soluble in DMSO. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
~752.4° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LX8930000
PubChem CID :
MDL Number :
MFCD00151702
Beilstein Registry :
4834067
SMILES :
CO[[email protected]]1C[[email protected]](C)[[email protected]@H](OC)C2=CC(=O)C=C(NC(=O)\\C(C)=C\\C=C/[[email protected]](OC)[[email protected]@H](OC(N)=O)\\C(C)=C\\[[email protected]](C)[[email protected]]1OC)C2=O

Download SDS (MSDS)

Certificate of Analysis

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Herbimycin A (CAS 70563-58-5)  Product Citations

See how others have used Herbimycin A (CAS 70563-58-5). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 12 total

PMID: # 32213627  Lek, A.|Zhang, Y.|Woodman, KG.|Huang, S.|DeSimone, AM.|Cohen, J.|Ho, V.|Conner, J.|Mead, L.|Kodani, A.|Pakula, A.|Sanjana, N.|King, OD.|Jones, PL.|Wagner, KR.|Lek, M.|Kunkel, LM.| et al. 2020. Sci Transl Med. 12:

PMID: # 24729485  Wang, X. et al. 2014. J. Cell. Physiol. 229: 1981-9.

PMID: # 25286253  Bhowmick, R. et al. 2014. PLoS ONE. 9: e109107.

PMID: # 12714438  Gudi, S. et al. 2003. Arterioscler Thromb Vasc Biol. 23: 994-1000.

PMID: # 12821041  Milliano, MT. et al. 2003. J. Hepatol. 39: 32-37.

PMID: # 9927501  Chen, Z. et al. 1999. J. Clin. Invest. 103: 401-406.

PMID: # 10585406  Hu, P.P. et al. 1999. J. Biol. Chem. 274: 35381-35387.

PMID: # 9774438  Xu, G. et al. 1998. J. Biol. Chem. 273: 28178-28184.

PMID: # 9111069  Krejsa, CM. et al. 1997. J. Biol. Chem. 272: 11541-11549.

PMID: # 8702786  Szabò, I. et al. 1996. J. Biol. Chem. 271: 20465-20469.

Citations 1 to 10 of 12 total

hi, i bought the inhibitor of Herbimycin A (CAS 70563-58-5) , but i am not sure how much volum of DMSO should i use to disolve 100µg Herbimycin. Do you have a recommendation?

Asked by: X Wang
Herbimycin A (CAS 70563-58-5) sc-3516 can be dissolved in DMSO with a concentration of up to 7.5 mg/ml. If you are having trouble dissolving Herbimycin A try gently heating the solvent and stir continuously.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-30
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Rated 5 out of 5 by from Gudi Gudi, et. al. (PubMed ID 12714438) found that Herbimycin A can inhibit shear induced Ras activation of the ERK and JNK pathways. -SCBT Publication Review
Date published: 2015-07-12
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