HeracleninCAS: 2880-49-1, MF: C16H14O5, MW: 286.3

Heraclenin (CAS 2880-49-1)

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CAS Number: 2880-49-1
Molecular Weight: 286.3
Molecular Formula: C16H14O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Heraclenin inhibits T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Heraclenin also induces apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.


References

1. Schimmer, O., et al., . Mutagenicity of a furocoumarin epoxide, heraclenin, in Chlamydomonas reinhardii. Mutation research. 169(1-2): 47-50. PMID: 3945236
2. Abel, G., et al., . Chromosome-damaging effects of heraclenin in human lymphocytes in vitro. Mutation research. 169(1-2): 51-4. PMID: 3945237
3. Mishra, K C., et al., 1969. Anticoagulant activity of Heraclenin. Indian journal of physiology and pharmacology. 13(3): 153-5. PMID: 5362630
4. Appendino, Giovanni., et al., 2004. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin. Journal of natural products. 67(4): 532-6. PMID: 15104479

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
182251
SMILES :
CC1(C(O1)COC2=C3C(=CC4=C2OC=C4)C=CC(=O)O3)C

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