Heptakis(2,3-dimethyl)-β-cyclodextrin (CAS 123155-05-5)

Heptakis(2,3-dimethyl)-β-cyclodextrin is a modified cyclodextrin with seven glucose units in a cyclic arrangement, featuring methyl groups at the 2 and 3 positions of each sugar. This structure alters the inner cavity and hydrophobicity of the molecule, making it a valuable tool in chemical research. Its hydrophobic cavity can encapsulate various hydrophobic compounds, facilitating studies on host-guest chemistry, inclusion complexes, and molecular encapsulation. The methylation enhances solubility in organic solvents and provides greater thermal stability, enabling its use in research involving complexation efficiency under various environmental conditions. Researchers have employed it in analytical chemistry to improve the separation of enantiomers and enhance the performance of chromatographic techniques by stabilizing enantiomeric inclusion complexes. Its role in stabilizing hydrophobic molecules has advanced the understanding of molecular interactions and the influence of substitution patterns on complex formation. Studies using this cyclodextrin derivative have also explored how structural modifications affect binding affinity with various guests, providing insight into designing targeted delivery systems, improving solubilization, and investigating mechanisms of supramolecular recognition. Overall, Heptakis(2,3-dimethyl)-β-cyclodextrin offers a versatile platform for research across analytical chemistry, material science, and molecular recognition.