Date published: 2025-12-31

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HEPPSO (CAS 68399-78-0)

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Alternate Names:
N-(2-Hydroxyethyl)piperazine-N′-2-hydroxypropanesulphonic acid
CAS Number:
68399-78-0
Purity:
≥99%
Molecular Weight:
268.33
Molecular Formula:
C9H20N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Heppso, a synthetic compound modeled after heparin, excels in laboratory research due to its enhanced stability and resistance to breakdown. Its applications in research are diverse and increasing in popularity, encompassing areas such as cell culture, protein purification, and improving compound solubility. In the realm of cell culture, Heppso is instrumental in minimizing cell adhesion and clustering while promoting cellular proliferation and differentiation. During protein purification processes, it is valuable for its ability to latch onto specific proteins, facilitating their clean separation from other proteins in the mix. With regards to solubility, Heppso plays a role in enhancing the dissolution of certain compounds, easing their study within biological applications. Its propensity for forming stable complexes with proteins, along with its compatibility with various metal ions, renders Heppso a key asset in a range of experimental procedures.


HEPPSO (CAS 68399-78-0) References

  1. Characterisation of a thermophilic L-glutamate dehydrogenase biosensor for amperometric determination of L-glutamate by flow injection analysis.  |  Pasco, N., et al. 1999. Biosens Bioelectron. 14: 171-8. PMID: 10101839
  2. Complexation of copper by zwitterionic aminosulfonic (good) buffers.  |  Mash, HE., et al. 2003. Anal Chem. 75: 671-7. PMID: 12585500
  3. Use of molybdate as novel complex-forming selector in the analysis of polyhydric phenols by capillary zone electrophoresis.  |  Polásek, M., et al. 2006. Talanta. 69: 192-8. PMID: 18970553
  4. Oligosaccharide binding in Escherichia coli glycogen synthase.  |  Sheng, F., et al. 2009. Biochemistry. 48: 10089-97. PMID: 19761218
  5. Catalysis-reduction strategy for sensing inorganic and organic mercury based on gold nanoparticles.  |  Li, X., et al. 2017. Biosens Bioelectron. 92: 328-334. PMID: 27836598
  6. Effect of zwitterionic buffers on measurement of small masses of protein with bicinchoninic acid.  |  Kaushal, V. and Barnes, LD. 1986. Anal Biochem. 157: 291-4. PMID: 3777432
  7. Copper(II) complexation properties and surfactant activity of 3-[N, N-bis(2-hydroxyethyl)amino]-2-hydroxypropanesulfonic acid and N-(2-Hydroxyethyl)piperazine-N'-2-hydroxypropanesulfonic acid pH buffers which may affect trace metal speciation in in vitro studies.  |  Vasconcelos, MT., et al. 1998. Anal Biochem. 265: 193-201. PMID: 9882392
  8. Electrochemical investigations of the effect of N-substituted aminosulfonic acids with a piperazinic ring pH buffers on heavy metal processes which may have implications on speciation studies  |  HMVM Soares, PCFL Conde. 2000. Analytica Chimica Acta. 421, 1: 103-111.
  9. Influence of zwitterionic pH buffers on the bioavailability and toxicity of copper to the alga Amphidinium carterae  |   and M. Teresa S.D. Vasconcelos, Cristina M.R. Almeida, Olga M. Lage, Filipe Sansonetty. 2000. Environmental Toxicology and Chemistry. 19, 10: 2542-2550.
  10. Complexation Equilibria of Zn(II), Pb(II) and Cd(II) with Reduced Glutathione (GSH) and Biologically Important Zwitterionic Buffers  |   and Zeinab Mohamed Anwar. 2005. Journal of the Chinese Chemical Society. 52, 5: 863-871.
  11. Calorimetric determination of enthalpy changes for proton ionization of N-[2-hydroxyethyl]piperazine-N′-[2-ethane sulfonic acid] (HEPES) and N-[2-hydroxyethyl]piperazine-N′-[2-hydroxypropane sulfonic acid] (HEPPSO) in water–methanol mixtures  |  FH Jumean, NM Abdo. 2006. Thermochimica Acta. 447, 1: 112-114.
  12. Self-limiting synthesis of Au–Pd core–shell nanocrystals with a near surface alloy and monolayer Pd shell structure and their superior catalytic activity on the conversion of hexavalent chromium  |  X Li, C Li, D Xiang, C Zhang, L Xia, X Liu. 2019. Applied Catalysis B: Environmental. 253: 263-270.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

HEPPSO, 100 g

sc-263353
100 g
$216.00