HEMADOA high affinity and selective Adenosine A3-R agonist

HEMADO (CAS 403842-38-6)

HEMADO | CAS 403842-38-6 is rated 5.0 out of 5 by 1.
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Synonym: 2-(1-Hexynyl)-N-methyladenosine
Application: A high affinity and selective Adenosine A3-R agonist
CAS Number: 403842-38-6
Purity: ≥95%
Molecular Weight: 361.39
Molecular Formula: C17H23N5O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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HEMADO is a high affinity selective Adenosine A3-R agonist.


References

1. Volpini, R., et al. 2002. J. Med. Chem. 45: 3271-3279.
2. Klotz, K.N., et al. 2006. Eur. J. Pharmacol. 556: 14-18.

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Desiccate at 4° C
Refractive Index :
n20D 1.68
IC50 :
adenosine A2B receptor: EC5050 = 100 nM (human)
Ki Data :
adenosine A3 receptor: Ki= 1.1 nM (human); adenosine A1 receptor: Ki= 327 nM (human); adenosine A2A receptor: Ki= 1230 nM (human); adenosine A2Breceptor: Ki= >30000 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10981286
MDL Number :
MFCD06798373
SMILES :
CCCCC#CC1=NC2=C(C(=N1)NC)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Amani et al Amani et al. (PubMed ID 2387894) found that HEMADO may protect the heart against ischemia-reperfusion injury by decreasing CK-MB and LDH levels. -SCBT Publication Review
Date published: 2015-01-23
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