Helenalin is a potent antiinflammatory and antineoplastic agent. Helanalin induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-XL or Bcl-2 are overexpressed. It has also been shown to inhibit NF-kappa B.
Soluble in DMSO and Ethanol
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
TianTian, R. et al. (PubMed 25720435) used Helenalin, an inhibitor of NF- B, to demonstrate that shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF- B signaling pathway in human epidermoid carcinoma A431 cells. -SCBT Publication Review
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