HelenalinAn inhibitor of the transcription factor NFκB

Helenalin (CAS 6754-13-8)

Helenalin | CAS 6754-13-8 is rated 5.0 out of 5 by 1.
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Synonym: NF-κB inhibitor
Application: An inhibitor of the transcription factor NFκB
CAS Number: 6754-13-8
Purity: ≥97%
Molecular Weight: 262.30
Molecular Formula: C15H18O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Helenalin is a potent antiinflammatory and antineoplastic agent. Helanalin induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-XL or Bcl-2 are overexpressed. It has also been shown to inhibit NF-kappa B.

Physical State :
Solid
Solubility :
Soluble in DMSO and Ethanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23205
SMILES :
C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2

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Helenalin  Product Citations

See how others have used Helenalin. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27748869  Wan, J.|Shan, Y.|Fan, Y.|Fan, C.|Chen, S.|Sun, J.|Zhu, L.|Qin, L.|Yu, M.|Lin, Z.| et al. 2016. Mol Med Rep. 14: 4505-4510.

PMID: # 25810391  Bally, AP. et al. 2015. J. Immunol. 194: 4545-54.

PMID: # 24743449  O'Sullivan, MJ. et al. 2014. PLoS ONE. 9: e95566.

PMID: # 25423092  Yamada, H. et al. 2014. PLoS ONE. 9: e113834.

PMID: # 25268581  Song, FN. et al. 2014. PLoS ONE. 9: e108507.

Citations 1 to 5 of 5 total

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. Helenalin: sc-218579 is expected to be a white to off-white solid.
Answered by: Chemical Support 3
Date published: 2017-04-17

What is the solubility in DMSO?

Asked by: chemicalsmg
Thank you for your question. Helenalin: sc-218579 is soluble in DMSO at 10mg/ml.
Answered by: Chemical Support 3
Date published: 2017-04-17
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Rated 5 out of 5 by from Tian Tian, R. et al. (PubMed 25720435) used Helenalin, an inhibitor of NF- B, to demonstrate that shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF- B signaling pathway in human epidermoid carcinoma A431 cells. -SCBT Publication Review
Date published: 2015-06-02
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