HDSF is a serine-specific, active site-directed, modifying agent that acts as an irreversible inhibitor of Cln1 (palmitoyl-protein thioesterase-1 (Ki = 125 μM)). HDSF inhibits lipase, but not phospholipase C activity in Pseudomonas aeruginosa culture supernatant and phospholipase A activity in E. coli.
1. Horrevoets, A J., et al., 1991. Inactivation of Escherichia coli outer-membrane phospholipase A by the affinity label hexadecanesulfonyl fluoride. Evidence for an active-site serine. European journal of biochemistry / FEBS. 198(1): 247-53. PMID: 2040286
2. Kˆnig, B., et al., 1996. Infection and Immunity. 64: 322 3. Das, A K., et al., 2000. Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. The Journal of biological chemistry. 275(31): 23847-51. PMID: 10801859
See how others have used HDSF. Click on the entry to view the PubMed entry .
PMID: # 30251630 Brand, S.|Roy, S.|Schröder, P.|Rathmer, B.|Roos, J.|Kapoor, S.|Patil, S.|Pommerenke, C.|Maier, T.|Janning, P.|Eberth, S.|Steinhilber, D.|Schade, D.|Schneider, G.|Kumar, K.|Ziegler, S.|Waldmann, H.| et al. 2018. Cell Chem Biol. 25: 1095-1106.e23.
PMID: # 25867045 Potts, MB. et al. 2015. Nat. Chem. Biol. 11: 401-8.
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