HDSFA serien-specific, active site-directed, modifying agent that acts as an irreversible inhibitor

HDSF (CAS 86855-26-7)

HDSF | CAS 86855-26-7 is rated 5.0 out of 5 by 1.
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Synonym: Hexadecylsulfonyl Fluoride
Application: A serien-specific, active site-directed, modifying agent that acts as an irreversible inhibitor
CAS Number: 86855-26-7
Purity: ≥97%
Molecular Weight: 308.5
Molecular Formula: C16H33FO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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HDSF is a serine-specific, active site-directed, modifying agent that acts as an irreversible inhibitor of Cln1 (palmitoyl-protein thioesterase-1 (Ki = 125 μM)). HDSF inhibits lipase, but not phospholipase C activity in Pseudomonas aeruginosa culture supernatant and phospholipase A activity in E. coli.


References

1. Horrevoets, A J., et al., 1991. Inactivation of Escherichia coli outer-membrane phospholipase A by the affinity label hexadecanesulfonyl fluoride. Evidence for an active-site serine. European journal of biochemistry / FEBS. 198(1): 247-53. PMID: 2040286
2. Kˆnig, B., et al., 1996. Infection and Immunity. 64: 322 3. Das, A K., et al., 2000. Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. The Journal of biological chemistry. 275(31): 23847-51. PMID: 10801859

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.45 (Predicted)
Ki Data :
Cln1: Ki= 125 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3572
MDL Number :
MFCD03453550
Beilstein Registry :
4411921
SMILES :
CCCCCCCCCCCCCCCCS(=O)(=O)F

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Certificate of Analysis

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HDSF  Product Citations

See how others have used HDSF. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30251630  Brand, S.|Roy, S.|Schröder, P.|Rathmer, B.|Roos, J.|Kapoor, S.|Patil, S.|Pommerenke, C.|Maier, T.|Janning, P.|Eberth, S.|Steinhilber, D.|Schade, D.|Schneider, G.|Kumar, K.|Ziegler, S.|Waldmann, H.| et al. 2018. Cell Chem Biol. 25: 1095-1106.e23.

PMID: # 25867045  Potts, MB. et al. 2015. Nat. Chem. Biol. 11: 401-8.

Citations 1 to 2 of 2 total

Good afternoon, I was cutious whether there was any indication that, once resuspended in DMSO, this product is subject to loss off function from freeze thaw cycles?

Asked by: HOBO
It is recommended to use all of sc-221708 after re-suspension. If needed, the re-suspension should be aliquoted and stored at -20ºC. To prevent loss of function multiple freeze and thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2019-04-20
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Rated 5 out of 5 by from Leuveling Tjeenk M; et al Leuveling Tjeenk M; et al. (PubMed ID: 8029215) determined that HDSF inhibits Staphylococcus hyicus lipase. -SCBT Publication Review
Date published: 2015-06-22
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