HC ToxinAn HDAC inhibitor

HC Toxin (CAS 83209-65-8)

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Synonym: Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
Application: An HDAC inhibitor
CAS Number: 83209-65-8
Molecular Weight: 436.5
Molecular Formula: C21H32N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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HC Toxin is a potent, cell-permeable HDAC (histone deacetylase) inhibitor. HC Toxin inhibits HDACs in maize, Physarum and chicken. HC Toxin has displayed antiprotozoal and antineoplastic activity. HC toxin has induced the expression of the gamma-globin gene in erythroid cells. Antiproliferative activity against T47D human breast cancer cells and cultured mastocytoma cells has been observed with HC toxin treatment.


References

1. Walton, J D., et al., 1985. Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. Experientia. 41(3): 348-50. PMID: 3918884
2. Brosch, G., et al., 1995. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. The Plant cell. 7(11): 1941-50. PMID: 8535144
3. Ross, J., et al., 1996. Comments on the article "Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics" [(1996) Proc. Natl. Acad. Sci. USA 93, 7452-7453]. Proceedings of the National Academy of Sciences of the United States of America. 93(25): 14314; discussion 14315. PMID: 8962046
4. McCaffrey, P G., et al., 1997. Induction of gamma-globin by histone deacetylase inhibitors. Blood. 90(5): 2075-83. PMID: 9292546
5. Joung, Ki Eun., et al., 2004. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Archives of pharmacal research. 27(6): 640-5. PMID: 15283467
6. Walton, Jonathan D., et al., 2006. HC-toxin. Phytochemistry. 67(14): 1406-13. PMID: 16839576

Physical State :
Solid
Derived From :
Helminthosporium carbonium
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
Boiling Point :
819.18° C at 760 mmHg (Predicted)
Density :
1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
E. tenella HDAC: IC50 = 30 nM; Histone deacetylase 11: IC50 = 430 nM (human)
pK Values :
pKa: 13.33
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23724535
MDL Number :
MFCD00133388
SMILES :
CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3

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Certificate of Analysis

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HC Toxin  Product Citations

See how others have used HC Toxin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24227836  Shin, HJ. et al. 2014. J. Virol. 88: 1281-92.

Citations 1 to 1 of 1 total
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