HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.
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Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) at 40° C, and water (4 mg/ml) at 50° C (with vigorous agitation approximately 15 minutes).
Store at room temperature
pKa: 1.77, 8.03
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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please send me certification for chelate HBED.
and send me Comparison among chelates HBED with EDDHMA and EDTA
Asked by: meysam
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
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