Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil's Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.
1. García, D., et al. 1996. Farmaco. 51: 443-446. PMID: 8766229
2. Chantre, P., et al. 2000. Phytomedicine. 7: 177-183. PMID: 11185727
3. Kaszkin, M., et al. 2004. Phytomedicine. 11: 585-595. PMID: 15636171
4. Huang, T.H., et al. 2006. J Ethnopharmacol. 104: 149-155. PMID: 16203115
5. Günther, M., et al. 2006. Phytochem Anal. 17: 1-7. PMID: 16454469
6. Abdelouahab, N. and Heard, C. 2008. J. Nat. Prod. 71: 746-749. PMID: 18412394
7. Ouitas, N.A. and Heard, C. 2010. Phytother Res. 24: 333-338. PMID: 19610038
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.