HA14-1 is a small, cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action. HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.
1. Wang, J.L., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 7124-7129. PMID: 10860979
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Akl H; et alAkl H; et al. (PubMed ID: 26260683) determined HA14-1 enhanced BIRD-2-evoked Ca2+ release from the ER and apoptosis in both BIRD-2-sensitive diffuse large B-cell lymphoma cell lines and in primary B-cell chronic lymphocytic leukemia. -SCBT Publication Review
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