HA14-1A cell-permeable, nonpeptidic Bcl-2 inhibitor

HA14-1 (CAS 65673-63-4)

HA14-1 | CAS 65673-63-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_12, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_205911, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 85ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
Application: A cell-permeable, nonpeptidic Bcl-2 inhibitor
CAS Number: 65673-63-4
Purity: >95%
Molecular Weight: 409.23
Molecular Formula: C17H17BrN2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

HA14-1 is a small, cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action. HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.


References

1. Wang, J.L., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 7124-7129. PMID: 10860979

Physical State :
Solid
Solubility :
Soluble in DMSO (26 mg/mL), ethanol (100 mM), DMF, and halogenated solvents .
Storage :
Store at -20° C
Melting Point :
105-108° C
Boiling Point :
535.1° C at 760 mmHg
Density :
1.48 g/cm3
Refractive Index :
n20D 1.57
IC50 :
Flu-BakBH3 binding to Bcl-2: IC50 = ~9 µM
Ki Data :
Apoptosis regulator Bcl-X: Ki= 58.9 µM (human); Apoptosis regulator Bcl-W: Ki= 59.32 µM (human)
pK Values :
pKb: 3.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3549
MDL Number :
MFCD00218213
SMILES :
CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 62ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Akl H; et al Akl H; et al. (PubMed ID: 26260683) determined HA14-1 enhanced BIRD-2-evoked Ca2+ release from the ER and apoptosis in both BIRD-2-sensitive diffuse large B-cell lymphoma cell lines and in primary B-cell chronic lymphocytic leukemia. -SCBT Publication Review
Date published: 2015-01-31
  • y_2019, m_11, d_12, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_205911, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 36ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.