HA-1004 DihydrochlorideAn inhibitor of PKA, cGKI, PKC, MYLK, and calcium channel protein

HA-1004 Dihydrochloride (CAS 91742-10-8)

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Application: An inhibitor of PKA, cGKI, PKC, MYLK, and calcium channel protein
CAS Number: 91742-10-8
Purity: ≥97%
Molecular Weight: 366.26
Molecular Formula: C12H15N5O2S•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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HA-1004 has been shown to act as a potent inhibitor of PKA (cyclic AMP-dependent protein kinase), cGKI (cyclic GMP-dependent protein kinase), PKC, and MYLK at the intracellular or submembranal level. It has also been shown to act as calcium channel protein inhibitor and vasodilator, relaxing vascular smooth muscle.


References

1. Ishikawa, T., et al. 1985. J. Pharmacol. Exp. Ther. 235: 495-499. PMID: 2997436

Physical State :
Solid
Solubility :
Soluble in water (40 mg/ml), DMSO, and ethanol (10 mg/ml).
Storage :
Store at -20° C
Melting Point :
233-234° C
Boiling Point :
573.9° C at 760 mmHg
Refractive Index :
n20D 1.69
Ki Data :
protein kinase A: Ki= 2.3 µM; CaM kinase II: Ki= 13 µM; myosin light chain kinase: Ki= 150 µM; protein kinase C: Ki= 40 µM; protein kinase G: Ki= 1.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760499
MDL Number :
MFCD00069285
SMILES :
C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN=C(N)N.Cl.Cl

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Certificate of Analysis

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HA-1004 Dihydrochloride  Product Citations

See how others have used HA-1004 Dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25824204  Mohd Abdul Rashid, MB. et al. 2015. J Lab Autom. 20: 423-37.

Citations 1 to 1 of 1 total
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