H-Gly-Pro-Arg-Pro-OH Acetate SaltAn inhibitor of fibrinogen aggregation and fibrin polymerization

H-Gly-Pro-Arg-Pro-OH Acetate Salt (CAS 67869-62-9)

H-Gly-Pro-Arg-Pro-OH Acetate Salt | CAS 67869-62-9 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of fibrinogen aggregation and fibrin polymerization
CAS Number: 67869-62-9
Purity: ≥98%
Molecular Weight: 425.5 (free base)
Molecular Formula: C18H31N7O5•C2H4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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H-Gly-Pro-Arg-Pro-OH Acetate Salt can bind to the polymerization site (D domain) in fibrinogen (Ki = 400 mM) and prevent fibrinogen aggregation and fibrin polymerization. It also acts as an anticoagulant. Research shows that there is additional proteolysis of α, β and γ fibrinogen polypeptides during the cleavage of fibrinogen, which may also include the initial removal of fibrinopeptides.


References

1. Laudano, A.P., et al. 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 3085-3089. PMID: 277910
2. Hsieh, K.H., et al. 1981. J. Med. Chem. 24: 322-327. PMID: 7265118
3. Achyuthan, K.E., et al. 1986. Biochim. Biophys. Acta. 872: 261-268. PMID: 2873839
4. Dowd, A.J., et al. 1995. Eur. J. Biochem. 232: 241-246. PMID: 7556157
5. Rijkers, D.T., et al. 1998. Thromb. Res. 89: 161-169. PMID: 9651143

Appearance :
Lyophilized powder
Physical State :
Solid
Solubility :
Soluble in 0.05 M acetic acid, and water (partly).
Storage :
Store at -20° C
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44134745
SMILES :
CC(=O)O.C1CC(N(C1)C(=O)CN)C(=O)NC(CCCN=C(N)N)C(=O)N2CCCC2C(=O)O

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H-Gly-Pro-Arg-Pro-OH Acetate Salt  Product Citations

See how others have used H-Gly-Pro-Arg-Pro-OH Acetate Salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 277910  Laudano, AP. et al. 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 3085-3089.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Dowd Dowd, AJ. et al. (PubMed 7556157) reported that Fasciola hepatica cathepsin L proteinase cleaves fibrinogen and produces a novel type of fibrin clot. Clot formation by cathepsin L is not inhibited by the thrombin inhibitor hirudin or by the anti-polymerant H-Gly-Pro-Arg-Pro-OH. -SCBT Publication Review
Date published: 2015-03-12
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