H-9 hydrochlorideA potent and competitive inhibitor of protein kinase C, cAMP-dependent protein kinase, and cGMP

H-9 hydrochloride (CAS 116970-50-4)

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Application: A potent and competitive inhibitor of protein kinase C, cAMP-dependent protein kinase, and cGMP
CAS Number: 116970-50-4
Purity: >99%
Molecular Weight: 287.77
Molecular Formula: C11H13N3O2S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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H-9 hydrochloride inhibits PKA (Ki=1.9 μM), PKC (Ki=18 μM; cGKI (PKG) =0.87 μM; MLCK=70 μM). It has shown to dramatically reduce the GABA response of GABAA currents in retinal rod bipolar cells as well as inhibit smooth muscle cell relaxation induced by cGRP. H-9 dihydrochloride has also been used for purification of protein kinases in ligand affinity chromatography.


References

1. Wolf, M., et al. 1985. J. Biol. Chem. 260: 15718-15722. PMID: 4066694
2. Inagaki, M., et al. 1985. J. Biol. Chem. 260: 2922-2925. PMID: 2982842
3. Gillette, M.A., et al. 1996. J. Neurophysiol. 76: 3070-3086. PMID: 8930256
4. Boyer, J.C., et al. 1998. Biochem. Pharmacol. 56: 1097-1104. PMID: 9802318
5. Holohean, A.M. and Hackman, J.C. 2004. Br. J. Pharmacol. 143: 351-360. PMID: 15339859

Physical State :
Solid
Solubility :
Soluble in water (Partly miscible), and methanol.
Storage :
Store at -20° C
Melting Point :
250-255° C (dec.)
Ki Data :
µM: Ki= PKA 1.9; µM: Ki= PKC 18; µM: Ki= PKG 0.87; µM: Ki= MLCK 70
pK Values :
pKa: 8.26, pKb: 10.97
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NX4897000
PubChem CID :
3088099
MDL Number :
MFCD00083242
Beilstein Registry :
6548866
SMILES :
C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN.Cl

Download SDS (MSDS)

Certificate of Analysis

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