GYKI 53655 hydrochloride

GYKI 53655 hydrochloride (CAS 143692-48-2)

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Synonym: 1-(4-Aminophenyl)-3-methylcarbamyl- 4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-ben zodiazepine hydrochloride
Application: A non-competitive AMPA and kainate receptor antagonist
CAS Number: 143692-48-2
Molecular Weight: 388.85
Molecular Formula: C19H20N4O3•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. This compound has also been shown to block GluK3 homomeric receptors (IC50 = 63 µM) and GluK2b(R)/GluK3 heteroreceptors at high concentrations. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
IC50 :
GluK3 homomeric receptors: IC50 = 63 µM; GluK2b(R)/GluK3 heteroreceptors : IC50 = 32 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
JI4631600
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
126757
MDL Number :
MFCD01941362
SMILES :
CC1CC2=CC3=C(C=C2C(=NN1C(=O)NC)C4=CC=C(C=C4)N)OCO3.Cl

Download SDS (MSDS)

Certificate of Analysis

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