GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. This compound has also been shown to block GluK3 homomeric receptors (IC50 = 63 µM) and GluK2b(R)/GluK3 heteroreceptors at high concentrations. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
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