GYKI 47261 dihydrochlorideA non-competitive AMPA antagonist receptor

GYKI 47261 dihydrochloride (CAS 220445-20-5)

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Application: A non-competitive AMPA antagonist receptor
CAS Number: 220445-20-5
Purity: ≥99%
Molecular Weight: 395.71 (Anhydrous)
Molecular Formula: C18H15ClN42HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Non-competitive AMPA antagonist receptor (IC50 = 2.5 μM). In vivo, displays broad spectrum anticonvulsive activity and neuroprotective effects.


References

Abraham et al (2000) New non competitive AMPA antagonists. Bioorg.Med.Chem. 8 2127. Solyom (2001) Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie 25 Suppl.1 S62. Bibbiani et al (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 196 422.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.71
IC50 :
GluR: IC50 = 2.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46861544
SMILES :
CC1=CN2C(=N1)CC3=C(C=C(C=C3)Cl)C(=N2)C4=CC=C(C=C4)N.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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