GW 9578

GW 9578 (CAS 247923-29-1)

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Synonym: 2- [[4- [2- [[[(2, 4- difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]- 2- methyl- propanoic acid
Application: A potent agonist of PPARα
CAS Number: 247923-29-1
Molecular Weight: 492.6
Molecular Formula: C26H34F2N2O3S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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GW 9578 is a potent agonist of PPARα that activates the murine and human receptors with EC50 values of 0.005 and 0.05 μM, respectively. GW 9578 is highly selective for PPARα compared to PPARγ and PPARβ. GW 9578 is a potent lipid lowering agent.


1 Latruffe, N., Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997). 2 Lemberger, T., Desvergne, B., Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996). 3 Mandard, S., Müller, M., Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004). 4 Brown, P.J., Winegar, D.A., Plunket, K.D., et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity. J Med Chem 42 3785-3788 (1999). 5 Guerre-Millo, M., Gervois, P., Raspé, E., et al. Peroxisome proliferator-activated receptor a activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275 16638-16642 (2000).

Formulation :
A solution in methyl acetate
Physical State :
Storage :
Store at -20° C
Boiling Point :
57° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :

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Certificate of Analysis

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