GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ. This compound has also been found to cause an up-regulation of β-oxidation gene expression and an increase in palmitate oxidation. Additionally, glycolysis is strongly reduced at transcriptional levels by GW 7647 leading to a decrease in lactate and pyruvate production. Furthermore, this agent displays the ability to decrease glucose oxidation and inhibit lipogenesis and triglyceride esterification.
1. Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11: 1225-1227. PMID: 11354382 2. Cunard, R., et al. 2002. J. Immunol. 168: 2795-2802. PMID: 11884448 3. Paukkeri, E.L., et al. 2007. Br. J. Pharmacol. 152: 1081-1091. PMID: 17891158 4. Ribet, C., et al. 2010. Endocrinology. 151: 123-133. PMID: 19887568
Soluble in DMSO (50 mg/ml), and ethanol (12 mg/ml). Insoluble in water.
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LamLam, VH. et al. (PubMed 25977309) investigated whether stimulating fatty acid -oxidation with GW7647, a peroxisome proliferator-activated receptor- (PPAR ) activator, would improve cardiac energy production and post-ischemic functional recovery in neonatal rabbit hearts subjected to volume overload-induced cardiac hypertrophy. Found that GW7647 treatment increased cardiac fatty acid -oxidation rates before and after ischemia, which resulted in a significant increase in overall ATP production and an improved in vitro post-ischemic functional recovery. -SCBT Publication Review
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