Guanylyl Imidodiphosphate (CAS 148892-91-5)
Guanylyl Imidodiphosphate is the preferred GTP analog to activate ADP-ribosylation factor. It binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
References
1. Hepler, J.R., and Gilman, A.G., G proteins. Trends Biochem. Sci. 17, 383-387, (1992) 2. Miller, J.D., and Walter, P., A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. Ciba Found. Symp. 176, 147-163, (1993); 3. Connolly, T., et al., Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science 252, 1171-1173, (1991) 4. Gill, D.M., and Woolkalis, M.J., Cholera toxin-catalyzed [32P]ADP-ribosylation of proteins. Meth. Enzymol. 195, 267-280, (1991)
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