Guanylyl Imidodiphosphate is the preferred GTP analog to activate ADP-ribosylation factor. It binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.
1. Hepler, J.R., and Gilman, A.G., G proteins. Trends Biochem. Sci. 17, 383-387, (1992) 2. Miller, J.D., and Walter, P., A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. Ciba Found. Symp. 176, 147-163, (1993); 3. Connolly, T., et al., Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science 252, 1171-1173, (1991) 4. Gill, D.M., and Woolkalis, M.J., Cholera toxin-catalyzed [32P]ADP-ribosylation of proteins. Meth. Enzymol. 195, 267-280, (1991)
Guanylyl Imidodiphosphate is soluble is water, 50 mg/ml
Soluble in water (50 mg/ml).
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
Hi, do you have have a protocol for how to use Guanylyl Imidodiphosphate (CAS 148892-91-5)?
Asked by: qhyichao2012
Thank you for your question. There is a reference for this product on the product page (PMID 8299417) and there is additional information, literature, and publications at
Rated 5 out of
Guanylyl imidodiphosphate binds tightly toGuanylyl imidodiphosphate binds tightly to guanine nucleotide-binding proteins (G-proteins) in the presence of magnesium (PubChem). -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.