Guanylyl ImidodiphosphateAn ADP-ribosylation factor activator

Guanylyl Imidodiphosphate (CAS 148892-91-5)

Guanylyl Imidodiphosphate | CAS 148892-91-5 is rated 5.0 out of 5 by 1.
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Synonym: GMP-PNP; Guanosine 5′-[β,γ-imido]triphosphate trisodium salt
Application: An ADP-ribosylation factor activator
CAS Number: 148892-91-5
Purity: ≥85%
Molecular Weight: 588.14
Molecular Formula: C10H14N6O13P33Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Guanylyl Imidodiphosphate is the preferred GTP analog to activate ADP-ribosylation factor. It binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.


References

1. Hepler, J.R., and Gilman, A.G., G proteins. Trends Biochem. Sci. 17, 383-387, (1992) 2. Miller, J.D., and Walter, P., A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. Ciba Found. Symp. 176, 147-163, (1993); 3. Connolly, T., et al., Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science 252, 1171-1173, (1991) 4. Gill, D.M., and Woolkalis, M.J., Cholera toxin-catalyzed [32P]ADP-ribosylation of proteins. Meth. Enzymol. 195, 267-280, (1991)

Usage :
Guanylyl Imidodiphosphate is soluble is water, 50 mg/ml
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
230° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219382
MDL Number :
MFCD00084770
SMILES :
C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(NP(=O)(O)[O-])[O-])O)O)NC(=NC2=O)N.[Na+].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Hi, do you have have a protocol for how to use Guanylyl Imidodiphosphate (CAS 148892-91-5)?

Asked by: qhyichao2012
Thank you for your question. There is a reference for this product on the product page (PMID 8299417) and there is additional information, literature, and publications at https://pubchem.ncbi.nlm.nih.gov/compound/36735 #section=Literature
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

How is the purity tested?

Asked by: two2igm05
The purity of the compound is tested via HPLC.
Answered by: Chemical Support 4
Date published: 2017-02-28
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Rated 5 out of 5 by from Guanylyl imidodiphosphate binds tightly to Guanylyl imidodiphosphate binds tightly to guanine nucleotide-binding proteins (G-proteins) in the presence of magnesium (PubChem). -SCBT Publication Review
Date published: 2015-01-21
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