Guanylin (human)An endogenous guanylyl cyclase activator

Guanylin (human) (CAS 183200-12-6)

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Application: An endogenous guanylyl cyclase activator
CAS Number: 183200-12-6
Purity: ≥96%
Molecular Weight: 1458.7
Molecular Formula: C58H87N15O21S4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Guanylin (human) is an endogenous intestinal GCS (guanylyl cyclase) activator.


References

Guanylin: an endogenous activator of intestinal guanylate cyclase: M.G. Currie, et al.; PNAS 89, 947 (1992) Precursor structure, expression, and tissue distribution of human guanylin: F.J. de Sauvage, et al.; PNAS 89, 9089 (1992) Human guanylin: cDNA isolation, structure, and activity: R.C. Wiegand, et al.; FEBS Lett. 311, 150 (1992)

Appearance :
Lyophilized powder
Physical State :
Solid
Sequence :
H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH (Disulfide bonds between Cys4-Cys12 and Cys7-Cys15).
Solubility :
Soluble in water (1 mg/ml).
Storage :
Store at -20° C
Boiling Point :
1956.42° C at 760 mmHg (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD00187933
SMILES :
CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CCC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H]3CCCN3)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)C)Cc4ccc(cc4)O)C)C)[C@@H](C)O)C(=O)O

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Certificate of Analysis

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Guanylin (human)  Product Citations

See how others have used Guanylin (human). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23185490  Yu, L. et al. 2012. PloS one. 7: e49934.

Citations 1 to 1 of 1 total
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