Guanosine 5prime-O-(3-thiotriphosphate) tetralithium saltA G-protein-activating GTP analog

Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt (CAS 94825-44-2)

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Synonym: GTP-γ-S 4Li
Application: A G-protein-activating GTP analog
CAS Number: 94825-44-2
Molecular Weight: 562.98
Molecular Formula: C10H12N5O13P3S•4Li
* Refer to Certificate of Analysis for lot specific data (including water content).
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Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt is a Gβ-activating (G-protein-activating) GTP analog, which is more resistant to hydrolysis than GTP. Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.


References

1.Lino, S., et al. 2000. FEBS Lett. 479, 46. 2.Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182. 3.Hess, S.D., et al. 1993. Science 259, 1169. 4.Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183. 5.McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117. Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66. 6.Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466. 7.Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615. 8.Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (≥75 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.95 (Predicted)
Ki Data :
Kappa opioid receptor: Ki= 0.0048 nM (human)
pK Values :
pKa: 0.97 (Predicted), pKb: 2.42 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44134755
MDL Number :
MFCD00135151
EC Number :
305-606-1
Beilstein Registry :
8182249
SMILES :
[Li+].[Li+].[Li+].[Li+].NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]2O)C(=O)N1

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Certificate of Analysis

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Hi, What's the purity of the product: Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt, 10 mg sc-202639 Thank you

Asked by: Manky
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-07-31
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