Guanabenz acetateAn α2A-AR agonist and IGRS selective ligand

Guanabenz acetate (CAS 23256-50-0)

Guanabenz acetate | CAS 23256-50-0 is rated 5.0 out of 5 by 2.
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Application: An α2A-AR agonist and IGRS selective ligand
CAS Number: 23256-50-0
Purity: ≥98%
Molecular Weight: 291.14
Molecular Formula: C8H8Cl2N4.CH3CO2H
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Guanabenz acetate is an α2A-AR adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand. Guanabenz acetate is an activator of alpha2B-AR (α2b-adrenergic receptor) and alpha2C-AR (α2c-adrenergic receptor).


References

1. Holmes, B., et al. 1983. Drugs. 26: 212-229.
2. Michel, M.C. and Insel, P.A. 1989. Trends Pharmacol Sci. 10: 342-344.
3. Evans, R.G. and Anderson, W.P. 1995. Br. J. Pharmacol. 116: 1557-1570.

Physical State :
Solid
Solubility :
Soluble in DMSO (75 mM), water (11 mg/ml at 25° C), alcohol (50 mg/ml at 25° C), chloroform (0.6 mg/ml at 25° C), and propylene glycol (100 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
192.5° C (dec.)
Boiling Point :
405.7° C at 760 mmHg (tautomer)
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 3.16 µM
pK Values :
pKa: 8.1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MF0382000
PubChem CID :
5702062
MDL Number :
MFCD00153801
EC Number :
245-534-7
SMILES :
CC(=O)O.C1=CC(=C(C(=C1)Cl)/C=N/N=C(N)N)Cl

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Certificate of Analysis

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Rated 5 out of 5 by from Inhibitor of eIF2α dephosphorylation Efficient for inhibiting eIF2α (α-subunit of eukaryotic initiation factor 2) dephosphorylation in the parasitic protist Toxoplasma.
Date published: 2017-09-05
Rated 5 out of 5 by from Vieira Vieira, FG. et al. (PubMed 26288094) reported that Guanabenz treatment accelerated disease in a mutant SOD1 mouse model of ALS. -SCBT Publication Review
Date published: 2015-01-30
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