GTP 14564 (CAS 34823-86-4)

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See product citations (3)

Application: GTP 14564 is a specific inhibitor of class III receptor tyrosine kinases

CAS Number: 34823-86-4

Purity: >98%

Molecular Weight: 234.26

Molecular Formula: C₁₅H₁₀N₂O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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GTP 14564 is a cell-permeable tricyclic benzofurano-indazolo compound which functions as a specific inhibitor of class III receptor tyrosine kinases. Studies show that GTP 14564 can be used to track the signaling pathways activated by FLT3 and ITD-FLT3 in Ba/F3 cells. Furthermore, GTP 14564 can suppress the FLT3 internal tandem duplication (ITD) cells to the same extent as FLT3 siRNA. Studies show that if combined with 17-AAG, GTP 14564 can reduce the levels of p-FLT3 and p-STAT5 and can amplify apoptosis and G0/G1 arrest in FLT3-ITD cells. GTP 14564 is an inhibitor of c-Fms-CSF-1R, c-Kit, Flt-3/Flk-2 and PDGFR-beta.

References

1. Murata, K. et al. 2003. J. Biol. Chem. 278(35): 32892-32898. PMID: 12815052

2. Yao, Q. et al. 2005. Leukemia. 19(9): 1605-1612. PMID: 16034464

Physical State :

Solid

Solubility :

Soluble in DMSO (100 mM), and ethanol (25 mM).

Storage :

Store at 4° C

Melting Point :

174.96° C (Predicted)

Boiling Point :

~459.1° C at 760 mmHg (Predicted)

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.74 (Predicted)

IC50 :

c-Fms: IC₅₀ = 0.3 µM; c-Kit: IC₅₀ = 0.3 µM; wt-FLT3 : IC₅₀ = 0.3 µM; ITD-FLT3: IC₅₀ = 0.3 µM; PDGFRβ: IC₅₀ = 1.0 µM

pK Values :

pK_a: 12.72 (Predicted), pK_b: 1.57 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

3385203

MDL Number :

MFCD01416326

SMILES :

C1=CC=C(C=C1)C2=NNC3=C2OC4=CC=CC=C43

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Certificate of Analysis

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