GSK2126458CAS: 1086062-66-9
MF: C25H17F2N5O3S
MW: 505.50
An inhibitor of p110 mutants.

GSK2126458 (CAS 1086062-66-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 110ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide
Application: An inhibitor of p110 mutants
CAS Number: 1086062-66-9
Purity: ≥98%
Molecular Weight: 505.50
Molecular Formula: C25H17F2N5O3S
* Refer to Certificate of Analysis for lot specific data (including water content).

GSK2126458 is a potent inhibitor of common activating mutants of p110α (E542K, E545K, and H1047R), with Ki values of 8 pM, 8 pM and 9 pM, respectively. GSK2126458 causes a significant reduction in the levels of pAkt-S473 in T47D and BT474 cells with an IC50 of 0.41 nM and 0.18 nM, respectively. GSK2126458 leads to a G1 cell cycle arrest and produces the inhibitory effect on cell proliferation in a large panel of cell lines, including T47D and BT474 breast cancer lines with IC50 of 3 nM and 2.4 nM, respectively. GSK2126458 is an inhibitor of mTOR, PI 3-kinase p110 α, PI 3-kinase p110 β, PI 3-kinase p110 δ and PI 3-kinase p110 γ.

Physical State :
Solubility :
Soluble in DMSO (100 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Storage :
Store at -20° C
Boiling Point :
715.59 °C at 760 mmHg (Predicted)
Density :
1.45 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Ki Data :
p110α: Ki= 0.02 nM; p110δ: Ki= 0.02 nM; p110γ: Ki= 0.06 nM; p110β: Ki= 0.13 nM; mTORC1: Ki= 0.18 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 158ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.