GSK J1A selective and potent inhibitor of JMJDE and UTX demethylases

GSK J1 (CAS 1373422-53-7)

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Synonym: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Application: A selective and potent inhibitor of JMJDE and UTX demethylases
CAS Number: 1373422-53-7
Purity: ≥98%
Molecular Weight: 389.45
Molecular Formula: C22H23N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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GSK J1 is a selective and potent inhibitor of the H3K27 histone demethylases JMJDE and UTX. Suggested to display no activity against other JMJD family demethylases, and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 μM.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at 4° C
Boiling Point :
~608.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
JMJD3: IC50 = 60 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
56963315
MDL Number :
MFCD22683851
SMILES :
C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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