GSK-3 Inhibitor XA selective GSK-3α/β inhibitor

GSK-3 Inhibitor X (CAS 740841-15-0)

GSK-3 Inhibitor X | CAS 740841-15-0 is rated 5.0 out of 5 by 1.
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Synonym: BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA
Application: A selective GSK-3α/β inhibitor
CAS Number: 740841-15-0
Purity: ≥95%
Molecular Weight: 398.21
Molecular Formula: C18H12BrN3O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
236.83° C (Predicted)
Boiling Point :
551.87° C (Predicted)
Density :
1.69 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
GSK-3α/β: IC50 = 10 nM; Cdk5/p25: IC50 = 2.4 µM; Cdk2/A: IC50 = 4.3 µM; Cdk1/B: IC50 = 63 µM; Cdk4/D1: IC50 = ≥10 µM; aryl hydrocarbon receptor: EC5050 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC5050 = 0.16 µM (mammalian)
pK Values :
pKa: 9.23 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
6538818
MDL Number :
MFCD09037533
SMILES :
CC(=O)ONC1=C2C=CC=CC2=NC1=C3C4=C(C=C(C=C4)Br)NC3=O

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GSK-3 Inhibitor X  Product Citations

See how others have used GSK-3 Inhibitor X. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26743080  Vattulainen-Collanus, S. et al. 2016. J. Cell. Sci. 129: 693-705.

PMID: # 26022506  Dzobo, K. et al. 2015. Stem cell reviews. 11: 761-73.

PMID: # 22532441  Peng, H. et al. 2012. FASEB J. 26: 3140-7.

Citations 1 to 3 of 3 total

Is sc-221689 cell permeable?

Asked by: ChemSynth123
Thank you for your question. GSK-3 Inhibitor X (CAS 740841-15-0): sc-221689 is cell permeable.
Answered by: Chemical Support 7
Date published: 2017-03-02
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Rated 5 out of 5 by from Hsu Hsu, MJ. et al. (PubMed 23392633) reported that the GSK-3 inhibitor, BIO-acetoxime, may suppress viral gene expression and protect oral epithelial cells from HSV-1 infection. -SCBT Publication Review
Date published: 2015-03-14
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