GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
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HsuHsu, MJ. et al. (PubMed 23392633) reported that the GSK-3 inhibitor, BIO-acetoxime, may suppress viral gene expression and protect oral epithelial cells from HSV-1 infection. -SCBT Publication Review
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