GSK-3 Inhibitor IX, Control, MeBIOA cell-permeable N-methylated kinase inactive analog of GSK-3 Inhibitor IX

GSK-3 Inhibitor IX, Control, MeBIO (CAS 710323-61-8)

GSK-3 Inhibitor IX, Control, MeBIO | CAS 710323-61-8 is rated 5.0 out of 5 by 1.
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Synonym: 1-Methyl-BIO
Application: A cell-permeable N-methylated kinase inactive analog of GSK-3 Inhibitor IX
CAS Number: 710323-61-8
Purity: ≥97%
Molecular Weight: 370.2
Molecular Formula: C17H12BrN3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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GSK-3 Inhibitor IX, Control, MeBIO is a cell-permeable N-methylated kinase inactive analog of GSK-3 Inhibitor IX (sc-202634). The compound has been shown to act as a kinase negative control (IC50 > 92 μM for Cdc2 (Cdk1))/cyclin B, > 100 μM for Cdk5/p35 (p25), and GSK-3 α/GSK-3 β). MeBIO has been documented to act as a potent ligand for aryl hydrocarbon receptors at an EC50 = 20 nM for yeast and and EC50 =93 nM for hepatoma reporter systems. GSK-3 Inhibitor IX, Control, MeBIO has also demonstrated antiproliferative properties.


References

1. Meijer, L., et al. 2003. Chem. Biol. 10: 1255-1266. PMID: 14700633
2. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47: 935-946. PMID: 14761195
3. Knockaert, M., et al. 2004. Oncogene. 23: 4400-4412. PMID: 15077192

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Boiling Point :
496.40° C at 760 mmHg (Predicted)
Density :
1.69 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Cdk1/B: IC50 = >92 µM; Cdk5/p25: IC50 = >100 µM; GSK-3α/β: IC50 = 5 nM; AhR: EC5050 = 20 nM (yeast); AhR: EC5050 = 93 nM (hepatoma reporter systems)
pK Values :
pKa: 10.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6538821
SMILES :
CN1C2=C(C=CC(=C2)Br)/C(=C/3\C(=C4C=CC=CC4=N3)NO)/C1=O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of the Various publications cite the use of the inactive GSK-3 Inhibitor IX analog as an effective control. -SCBT Publication Review
Date published: 2015-07-10
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