GSK-3 Inhibitor IX, Control, MeBIO is a cell-permeable N-methylated kinase inactive analog of GSK-3 Inhibitor IX (sc-202634). The compound has been shown to act as a kinase negative control (IC50 > 92 μM for Cdc2 (Cdk1))/cyclin B, > 100 μM for Cdk5/p35 (p25), and GSK-3 α/GSK-3 β). MeBIO has been documented to act as a potent ligand for aryl hydrocarbon receptors at an EC50 = 20 nM for yeast and and EC50 =93 nM for hepatoma reporter systems. GSK-3 Inhibitor IX, Control, MeBIO has also demonstrated antiproliferative properties.
1. Meijer, L., et al. 2003. Chem. Biol. 10: 1255-1266. PMID: 14700633 2. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47: 935-946. PMID: 14761195 3. Knockaert, M., et al. 2004. Oncogene. 23: 4400-4412. PMID: 15077192
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