GSA 10A smoothened (Smo) receptor agonist

GSA 10 (CAS 300833-95-8)

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Synonym: 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
Application: A smoothened (Smo) receptor agonist
CAS Number: 300833-95-8
Molecular Weight: 450.53
Molecular Formula: C26H30N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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GSA 10 is a smoothened (Smo) receptor agonist (EC50 = 1.2 μM). GSA 10 does not recognize the classic cyclopamine (sc-200929) binding site. It additonally does not promote Smo translocation to the primary cilium and is also strongly potentiated by cholera toxin and forskolin. GSA 10 also promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

Physical State :
Solid
Solubility :
Soluble in DMSO (0.5 mg/ml), DMF (~1 mg/ml), and aqueous solutions (sparingly).
Storage :
Store at -20° C
Boiling Point :
~620.2 °C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Smo: EC5050 = 1.2 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
54683103
MDL Number :
MFCD01128015
SMILES :
CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O

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Certificate of Analysis

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