Gramicidin from Bacillus aneurinolyticus (Bacillus brevis)A linear polypeptide antibiotic

Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) (CAS 1405-97-6)

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Application: A linear polypeptide antibiotic
CAS Number: 1405-97-6
Molecular Weight: 1882.3
Molecular Formula: C99H140N20O17
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Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) is a linear polypeptide antibiotic with a mixture of gramicidin A, B, C, and D. Gramicidin D is a channel-forming ionophore that flip-flops slowly across the membrane and is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers.


A. Pullman, Energy profiles in the gramicidin A channel, review. Q. Rev. Biophys. 20, 173, (1987) G.A. Brewer, and K. Florey (Eds.) Analytical Profiles of Drug Substances, (1979) 8, 179 Eytan, G.D., et al. J. Biol. Chem. 27, 12897-12902, (1996) Borgnia, M.J., et al. J. Biol. Chem. 27, 3163-3171, (1996)

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