GR 135531 CAS: 190277-13-5
MF: C14H17N3O3
MW: 275.31
An agonist of the melatonin MT3 receptors.

GR 135531 (CAS 190277-13-5)

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Alternate Names: 5-Methoxycarbonylamino-N-acetyltryptamine
Application: GR 135531 is an agonist of the melatonin MT3 receptors
CAS Number: 190277-13-5
Molecular Weight: 275.31
Molecular Formula: C14H17N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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GR 135531 is a putative MEL-1 (melatonin MT3 receptor) agonist, showing low affinity for melatonin receptors MEL-1A-R and MEL-1B-R in the hamster brain. Since GR 135531 binds to MT3 with such high affinity, this compound can be used to discriminate between the melatonin receptor subtypes (MEL-1A-R, MEL-1B-R, and MEL-1(MT3)).


References

1. Dubocovich, M.L. 1995. Trends Pharmacol. Sci. 16: 50-56. PMID: 7762083
2. Lucchelli, A., et al. 1997. Br. J. Pharmacol. 121: 1775-1781. PMID: 9283717

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), methanol, THF, and DMSO (~28 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
204.66° C (Predicted)
Boiling Point :
~525.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
NQO2: IC50 = 2.7 nM (human); MT3 melatonin binding site: IC50 = 2.7 nM (hamster); MEL-1A-R: IC50 = 100 nM (human); MEL-1B-R: IC50 = 4 µM (human)
pK Values :
pKb: 0.6 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00672678
SMILES :
CC(=O)NCCC1=CNC2=C1C=C(C=C2)NC(=O)OC

Download SDS (MSDS)

Certificate of Analysis

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