GP-pNA, Chromogenic SubstrateA chromogenic substrate for dipeptidyl peptidase IV

GP-pNA, Chromogenic Substrate (CAS 103213-34-9)

GP-pNA, Chromogenic Substrate | CAS 103213-34-9 is rated 5.0 out of 5 by 1.
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Synonym: Gly-Pro p-nitroanilide hydrochloride
Application: A chromogenic substrate for dipeptidyl peptidase IV
CAS Number: 103213-34-9
Purity: ≥97%
Molecular Weight: 328.75
Molecular Formula: C13H16N4O4·HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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GP-pNA, Chromogenic Substrate is a chromogenic substrate for CD26 (dipeptidyl peptidase IV, DPIV, DPPIV), DPP7/II, DPRP1 (DPP8), DPRP2 (DPP9), FAP, Angiotensinase C (PCP/PRCP), PREP/POP, and likely other prolyl peptidases. GP-pNA, Chromogenic Substrate has been employed in vitro for inhibitor screening, on cultured cells, and in biological fluids. Hydrolysis of GP-pNA, Chromogenic Substrate can be monitored at 405-410 nm.


References

1. Chen, Y.S., et al. 2004. Protein Expr. Purif. 35: 142-146. PMID: 15039077
2. Maes, M.B., et al. 2005. Biochem. J. 386: 315-324. PMID: 15487984
3. Bjelke, J.R., et al. 2006. Biochem. J. 396: 391-399. PMID: 16475979
4. Tsai, T.Y., et al. 2006. Bioorg. Med. Chem. Lett. 16: 3268-3272. PMID: 16581245
5. Shariat-Madar, Z., et al. 2004. Blood. 103: 4554-4561. PMID: 14996700
6. Haffner, C.D., et al. 2008. Bioorg. Med. Chem. Lett. 18: 4360-4363. PMID: 18606544
7. Aertgeerts, K., et al. 2004. Protein Sci. 13: 145-154. PMID: 14691230
8. Magnin, D.R., et al. 2004. J. Med. Chem. 47: 2587-2598. PMID: 15115400
9. Pereira, D.A., et al. 2003. Braz. J. Med. Biol. Res. 36: 567-578. PMID: 12715075
10. Hosono, O., et al. 1999. Clin. Immunol. 91: 283-295. PMID: 10370373

Physical State :
Solid
Sequence :
H-Gly-Pro-p-nitroanilide
Solubility :
Soluble in water (at least 150 mM).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219380
MDL Number :
MFCD00058170
SMILES :
C1CC(N(C1)C(=O)CN)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-].Cl

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Certificate of Analysis

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Rated 5 out of 5 by from Various publications have cited the use of Various publications have cited the use of the chromogenic substrate GP-pNA in vitro for inhibitor screening, on cultured cells, and in biological fluids. Hydrolysis of GP-pNA, Chromogenic Substrate can be monitored at 405-410 nm. -SCBT Publication Review
Date published: 2015-04-19
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