Gouml 6983 CAS: 133053-19-7
Gö 6983 is a PKC inhibitor that selectively inhibits PKC isoenzymes.

Gö 6983 (CAS 133053-19-7)

Gandouml 6983 | CAS 133053-19-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Application: Gö 6983 is a PKC inhibitor that selectively inhibits PKC isoenzymes
CAS Number: 133053-19-7
Purity: ≥95%
Molecular Weight: 442.51
Molecular Formula: C26H26N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gö 6983 is a PKC inhibitor. Gö 6983 has been shown to selectively inhibit several PKC isoenzymes (IC50 = 7 nM for PKCα and PKCβ; 6nM for PKCγ; 10 nM for PKCδ; 60nM for PKCζ). The compound does not effectively inhibit PKCμ (IC50 = 20 μM) and therefore can be used to differentiate PKCμ from other isoforms.


References

1. Gschwendt, M., et al. 1996. FEBS Lett. 392: 77-80. PMID: 8772178
2. Stempka, L., et al. 1997. J. Biol. Chem. 272: 6805-6811. PMID: 9045715
3. Wang, D., et al. 1998. J. Biol. Chem. 273: 33027-33034. PMID: 9830056

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), DMF (~10 mg/ml), and 1:10 DMF:PBS (pH 7.2) (~0.1 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~709.0° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
PKCγ: IC50 = 6 nM; PKCα: IC50 = 7 nM; PKCβ: IC50 = 7 nM; PKCδ: IC50 = 10 nM; PKCζ: IC50 = 60 nM
pK Values :
pKa: 8.02 (Predicted), pKb: 9.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD04040031
SMILES :
CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Download SDS (MSDS)

Certificate of Analysis

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Gouml 6983 (CAS 133053-19-7)  Product Citations

See how others have used Gouml 6983 (CAS 133053-19-7). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 30104276  Spivak, AM.|Nell, RA.|Petersen, M.|Martins, L.|Sebahar, P.|Looper, RE.|Planelles, V.| et al. 2018. Antimicrob. Agents Chemother. 62:

PMID: # 28321180  Wang, J. et al. 2017. Front Cell Neurosci. 11: 57.

PMID: # 27903584  Madan, N. et al. 2017. Am. J. Physiol., Cell Physiol. 312: C222-C232.

PMID: # 27190091  Kim, JM.|Lee, M.|Kim, N.|Heo, WD.| et al. 2016. Proc Natl Acad Sci U S A. 113: 5952-7.

PMID: # 27103579  Fey, T. et al. 2016. FASEB J.

PMID: # 27660555  Ruedel, A. et al. 2016. Cancer Cell Int. 16: 71.

PMID: # 26689644  Ojani, R. et al. 2016. Insect Biochem. Mol. Biol. 70: 44-52.

PMID: # 26320174  Gato-Cañas, M. et al. 2015. Oncotarget. 6: 27160-75.

PMID: # 26378412  Yang, J. et al. 2015. Cell Cycle. 14: 3318-30.

PMID: # 25014309  Pandeló José, D. et al. 2014. Virology. 462-463: 328-39.

Citations 1 to 10 of 14 total
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Rated 5 out of 5 by from Hou Hou, J. et al. (PubMed 25830567) used G 6983 (Go 6983), a PKC inhibitor, to restore normal motility of stanniocalcin silenced breast cancer cells (231 HM). -SCBT Publication Review
Date published: 2015-03-14
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