Gö 6976 is a very potent PKC (protein kinase C ) inhibitor with high selectivity for the PKC isotypes α and β. Inhibits PKCα (IC50=2.3nM) and PKCβ1 (IC50=6.2nM) but has no effect on δ, ε or γ isotypes. Potent antagonist of HIV-1 induction. Gö 6976 is an inhibitor of JAK2, Trk A and Trk B.
1. Qatsha, K A., et al., 1993. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proceedings of the National Academy of Sciences of the United States of America. 90(10): 4674-8. PMID: 7685108 2. Wenzel-Seifert, K., et al., 1994. N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochemical and biophysical research communications. 200(3): 1536-43. PMID: 8185608 3. Martiny-Baron, G., et al., 1993. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. The Journal of biological chemistry. 268(13): 9194-7. PMID: 8486620 4. Gschwendt, M., et al., 1996. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS letters. 392(2): 77-80. PMID: 8772178
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RobinsonRobinson, KA. Et al. (PubMed 25330241) found that G 6976, an inhibitor of certain forms of PKC, Trks, and JAKs, reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes. -SCBT Publication Review
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