Golgicide A CAS: 1005036-73-6
MF: C17H14F2N2
MW: 284.30
A potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1.

Golgicide A (CAS 1005036-73-6)

Golgicide A | CAS 1005036-73-6 is rated 5.0 out of 5 by 1.
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Alternate Names: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Application: Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1
CAS Number: 1005036-73-6
Purity: ≥98%
Molecular Weight: 284.30
Molecular Formula: C17H14F2N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, which decreases Arf1 activation. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. The Arf activity cycle is initiated by the interaction of Arf1 with guanine nucleotide exchange factors (GEFs), which exchange GDP for GTP. Molecular modeling and mutagenesis revealed that Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. It is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.


References

Sáenz, J.B., et al., Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem. Biol., (2009)

Physical State :
Solid
Storage :
Store at room temperature
Boiling Point :
~383° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1C=C[[email protected]]2[[email protected]@H]1C(NC3=C(C=C(C=C23)F)F)C4=CN=CC=C4

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Golgicide A (CAS 1005036-73-6)  Product Citations

See how others have used Golgicide A (CAS 1005036-73-6). Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 28485883  Ignashkova, TI. et al. 2017. Traffic. 18: 530-544.

PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 28463988  Calton, CM.|Bronnimann, MP.|Manson, AR.|Li, S.|Chapman, JA.|Suarez-Berumen, M.|Williamson, TR.|Molugu, SK.|Bernal, RA.|Campos, SK.| et al. 2017. PLoS Pathog. 13: e1006200.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 29118074  Baumann, J. et al. 2017. Mol. Biol. Cell.

PMID: # 24185178  Reiling, JH. et al. 2013. Nature cell biology. 15: 1473-85.

PMID: # 27680705  Nature. 109-113.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from Prasad V; et al Prasad V; et al. (PubMed ID: 25187554) determined that Golgicide A, an GBF-1 inhibitor, triggered the unfolded protein response in cancer cells and human adenoviruses. -SCBT Publication Review
Date published: 2015-03-05
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