GODZ Antibody (A-10): sc-377378

GODZ Antibody (A-10) is a mouse monoclonal IgM antibody that detects GODZ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-GODZ antibody (A-10) is available as the non-conjugated form. The Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein, also known as Palmitoyltransferase ZDHHC3 or Zinc finger protein 373, is a 327 amino acid protein that plays a crucial role in palmitoylation and regulated trafficking of various substrates involved in synaptic function. Localized to the Golgi apparatus membrane, GODZ contains a DHHC-type zinc finger essential for palmitoyltransferase activity, which is vital for proper functioning of both inhibitory and excitatory synapses. GODZ is responsible for palmitoylation of the γ subunit 2 of GABA(A) receptors, a modification critical for maintaining normal synaptic GABAergic inhibitory function. GODZ interacts with glutamate receptors GRIA1 and GRIA2, facilitating their retention within the Golgi apparatus, thereby influencing synaptic plasticity and signaling. Two isoforms of GODZ, resulting from alternative splicing events, further highlight the complexity and regulatory potential in neuronal signaling pathways.

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GODZ Antibody (A-10) References:

1. Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain.  |  Uemura, T., et al. 2002. Biochem Biophys Res Commun. 296: 492-6. PMID: 12163046
2. GABARAP: lessons for synaptogenesis.  |  Coyle, JE. and Nikolov, DB. 2003. Neuroscientist. 9: 205-16. PMID: 15065816
3. The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ.  |  Keller, CA., et al. 2004. J Neurosci. 24: 5881-91. PMID: 15229235
4. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.  |  Hayashi, T., et al. 2005. Neuron. 47: 709-23. PMID: 16129400
5. GABAA receptor associated proteins: a key factor regulating GABAA receptor function.  |  Chen, ZW. and Olsen, RW. 2007. J Neurochem. 100: 279-94. PMID: 17083446
6. GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses.  |  Fang, C., et al. 2006. J Neurosci. 26: 12758-68. PMID: 17151279
7. Regulation of GABA(A)-receptor surface expression with special reference to the involvement of GABARAP (GABA(A) receptor-associated protein) and PRIP (phospholipase C-related, but catalytically inactive protein).  |  Kanematsu, T., et al. 2007. J Pharmacol Sci. 104: 285-92. PMID: 17690529
8. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport.  |  Goytain, A., et al. 2008. J Biol Chem. 283: 33365-74. PMID: 18794299
9. The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity.  |  Matakatsu, H. and Blair, SS. 2008. Curr Biol. 18: 1390-5. PMID: 18804377

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GODZ Antibody (A-10) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-GODZ Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GODZ Antibody (A-10) Specifications

Alternate Product Name: GODZ

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 297-327

Epitope Target: GODZ

Epitope Species: human

Product Reactivity/Detection: GODZ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for GODZ Antibody (A-10): P: Blocking Peptide