GnRHR Antibody (GRX-5): sc-69845

GnRHR Antibody (GRX-5) is a mouse monoclonal IgG1 antibody that detects the GnRHR protein of human origin by western blotting (WB) and immunofluorescence (IF). Anti-GnRHR antibody (GRX-5) is available as the non-conjugated format. The gonadotropin-releasing hormone receptor (GnRHR) plays a crucial role in the reproductive endocrine system by mediating the effects of gonadotropin-releasing hormone (GnRH), which is essential for the regulation of reproductive hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Located primarily in the pituitary gland, GnRHR is a member of the G-protein coupled receptor family and is characterized by its unique structure, which includes a seven transmembrane domain but notably lacks an intracellular C-terminal domain. This structural feature is significant as it influences the receptor′s signaling mechanisms and its interaction with downstream effectors. The GnRHR gene is intricately regulated by GnRH and activin A, and has been shown to undergo alternative splicing, which may contribute to the diversity of receptor isoforms and their functional implications in various physiological contexts. GnRHR monoclonal antibody (GRX-5) is an invaluable tool for researchers studying reproductive biology and related disorders.

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GnRHR Antibody (GRX-5) References:

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