Date published: 2026-5-4

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GM1-Pentasaccharide (CAS 52659-37-7)

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Alternate Names:
GM1-oligosaccharide
Application:
GM1-Pentasaccharide is a polysaccharide
CAS Number:
52659-37-7
Molecular Weight:
998.88
Molecular Formula:
C37H62N2O29
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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GM1-pentasaccharide, a specific oligosaccharide component of ganglioside GM1, has been extensively used in biochemical research to explore the intricacies of carbohydrate-protein interactions, particularly in the context of membrane biology and cellular signaling. This chemical serves as a crucial tool for investigating the binding specificity and mechanism of toxins, viruses, and other biomolecules that interact with ganglioside-containing cell membranes. In studies focused on molecular recognition, GM1-pentasaccharide has facilitated the understanding of how certain pathogens recognize and bind to host cells, a fundamental aspect of infection biology. Additionally, this oligosaccharide has been pivotal in the synthesis and study of complex glycoconjugates, contributing to the broader field of glycoscience by enabling researchers to dissect the functional roles of glycan structures in modulating biological processes. Through these applications, GM1-pentasaccharide aids in elucidating the structure-activity relationships within biological systems, offering insights into the roles that carbohydrates play in cellular communication and pathogen interaction. Its use in such research scenarios underscores its value in advancing basic scientific knowledge and enhancing our understanding of cellular dynamics at the molecular level.


GM1-Pentasaccharide (CAS 52659-37-7) References

  1. Molecular dynamics simulation of GM1 in phospholipid bilayer.  |  Roy, D. and Mukhopadhyay, C. 2002. J Biomol Struct Dyn. 19: 1121-32. PMID: 12023814
  2. Interferon-gamma: an overview of signals, mechanisms and functions.  |  Schroder, K., et al. 2004. J Leukoc Biol. 75: 163-89. PMID: 14525967
  3. T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1.  |  McCombe, PA. and Csurhes, PA. 2010. J Clin Neurosci. 17: 537-8. PMID: 20093028
  4. Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations.  |  Chebukati, JN., et al. 2010. Biochem Biophys Res Commun. 394: 509-14. PMID: 20206128
  5. Interactive configuration through force analysis of GM1 pentasaccharide-Vibrio cholera toxin interaction.  |  Seo, JH., et al. 2011. Anal Chem. 83: 6011-7. PMID: 21699239
  6. Characterization of the GM1 pentasaccharide-Vibrio cholera toxin interaction using a carbohydrate-based electrochemical system.  |  Seo, JH., et al. 2012. Analyst. 137: 2860-5. PMID: 22574310
  7. Binding of Vibrio cholera toxin and the heat-labile enterotoxin of Escherichia coli to GM1, derivatives of GM1, and nonlipid oligosaccharide polyvalent ligands.  |  Schengrund, CL. and Ringler, NJ. 1989. J Biol Chem. 264: 13233-7. PMID: 2666416
  8. On-chip biosynthesis of GM1 pentasaccharide-related complex glycans.  |  Kim, CS., et al. 2018. Chem Commun (Camb). 55: 71-74. PMID: 30507991
  9. How Choice of Model Membrane Affects Protein-Glycosphingolipid Interactions: Insights from Native Mass Spectrometry.  |  Han, L., et al. 2022. Anal Chem. 94: 16042-16049. PMID: 36367338
  10. Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide.  |  Merritt, EA., et al. 1994. Protein Sci. 3: 166-75. PMID: 8003954

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GM1-Pentasaccharide, 500 µg

sc-285869
500 µg
$800.00

GM1-Pentasaccharide, 1 mg

sc-285869A
1 mg
$1200.00