GM 6001 (CAS 142880-36-2)
GM 6001, a cell-permeable hydroxamic acid isomer, has been reported to potently inhibit human skin MMP-1 (fibroblast collagenase; Ki = 0.4nM) Additionally, this compound has been shown to act as an antagonist of TNFα release and processing in cells. Furthermore, GM 6001 has displayed the capacity to block several MMP (matrix metalloproteases), which are enzymes thought to be involved in angiogenesis. GM 6001, Negative Control is available as sc-295025. GM 6001 is an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MT-MMP-1 (MMP-14), MMP-26.
References
1. Grobelny, D., et al. 1992. Biochemistry. 31: 7152-7154. PMID: 1322694
2. Galardy, R.E., et al. 1994. Cancer Res. 54: 4715-4718. PMID: 7520359
3. Solorzano, C.C., et al. 1997. Shock. 7: 427-431. PMID: 9185243
4. Janssens, E. et al. 2013. PLoS ONE. 8(1): e52915. PMID: 23326364
Download SDS (MSDS)
SAMPLE Certificate of Analysis (COA)
GM 6001 | CAS 142880-36-2 SAMPLE Certificate of AnalysisCertificate of Analysis
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Appearance | Off-white solid | |
| Identification (NMR) | Consistent with structure | Complies |
| Purity | ≥ 95% |
GM 6001 (CAS 142880-36-2) Product Citations
See how others have used GM 6001 (CAS 142880-36-2). Click on the entry to view the PubMed entry .
PMID: 36009384 | Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds. | Betriu, N. et al. 2022. Biomedicines. 10:
PMID: 34108545 | Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer. | Huang, YH. et al. 2021. Sci Rep. 11: 12171.
PMID: 32800875 | Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging. | Quan, T. et al. 2020. J Invest Dermatol.
PMID: 31279213 | Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR. | Wang, J. et al. 2019. Sci. Total Environ. 689: 662-678.
PMID: 31294818 | In vitro lung cancer multicellular tumor spheroid formation using a microfluidic device. | Lee, SW. et al. 2019. Biotechnol. Bioeng.
PMID: 31249527 | Transcriptome Profiling Reveals Pro-Inflammatory Cytokines and Matrix Metalloproteinase Activation in Zika Virus Infected Human Umbilical Vein Endothelial Cells. | 2019. Front Pharmacol. 10: 642.
PMID: 31921836 | Thymosin β4 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and Invasion. | Makowiecka, A. et al. 2019. Front Cell Dev Biol. 7: 304.
PMID: 30718484 | Pioneer axons employ Cajal's battering ram to enter the spinal cord. | Nichols, EL. et al. 2019. Nat Commun. 10: 562.
PMID: 31496817 | OSM-induced CD44 contributes to breast cancer metastatic potential through cell detachment but not epithelial-mesenchymal transition. | Covert, H. et al. 2019. Cancer Manag Res. 11: 7721-7737.
PMID: 30105671 | An Antagonistic Axon-Dendrite Interplay Enables Efficient Neuronal Repair in the Adult Zebrafish Central Nervous System. | Beckers, A. et al. 2019. Mol. Neurobiol. 56: 3175-3192.