Gly-His-Lys acetate salt possesses a high affinity for copper(II) ions, with which it spontaneously forms a complex (GHK-Cu). This growth-modulating plasma tripeptide, when added at nanomolar concentrations to a wide group of cultured systems, produces a disparate set of responses ranging from the stimulation of growth and differentiation to outright toxicity. It may function by facilitating copper uptake into cells. GHK-Cu accelerates wound healing.
Pickart, L., et al. Biochem. Biophys. Res. Commun. 54, 562, (1973) Pickart, L., et al. J. Chromatogr. 175, 65, (1979)
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