Glucocorticoid Receptor Modulator, CpdA CAS: 14593-25-0
MF: C11H14ClNO2•HCl
MW: 264.15
A cell-permeable aziridine precursor.

Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0)

Glucocorticoid Receptor Modulator, CpdA | CAS 14593-25-0 is rated 5.0 out of 5 by 1.
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Alternate Names: 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
Application: Glucocorticoid Receptor Modulator, CpdA is a cell-permeable aziridine precursor
CAS Number: 14593-25-0
Purity: ≥97%
Molecular Weight: 264.15
Molecular Formula: C11H14ClNO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), and water (1 mg/ml).
Storage :
Store at -80° C
Melting Point :
184-191° C
Refractive Index :
n20D ~1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9838147
MDL Number :
MFCD16883076
SMILES :
CC(=O)OC1=CC=C(C=C1)C(CNC)Cl.Cl

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Certificate of Analysis

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Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0)  Product Citations

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PMID: # 25389358  Malaise, O. et al. 2015. Rheumatology (Oxford). 54: 1087-92.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Saksida Saksida, T. et al. (PubMed 25158597) reported that CpdA (Compound A), a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice. -SCBT Publication Review
Date published: 2015-02-09
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