Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), and water (1 mg/ml).
Store at -80° C
n20D ~1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SaksidaSaksida, T. et al. (PubMed 25158597) reported that CpdA (Compound A), a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice. -SCBT Publication Review
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