GlipizideA hypoglycemic agent that enhances insulin secretion

Glipizide (CAS 29094-61-9)

Glipizide | CAS 29094-61-9 is rated 5.0 out of 5 by 1.
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Synonym: Glydiazinamide; 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
Application: A hypoglycemic agent that enhances insulin secretion
CAS Number: 29094-61-9
Purity: ≥98%
Molecular Weight: 445.53
Molecular Formula: C21H27N5O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Glipizide is an ATP-dependent K+ channels blocker in pancreatic β cells and brain GABA containing neurons resulting in insulin release.


References

RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine: D. Raeburn & T.J. Brown; J. Pharmacol. Exp. Ther. 256, 480 (1991) Quantitative autoradiography of the binding sites for [125I] iodoglyburide, a novel high-affinity ligand for ATP-sensitive potassium channels in rat brain: D.R. Gehlert, et al.; J. Pharmacol. Exp. Ther. 257, 901 (1991) Brogden RN, Heel RC, Pakes GE et al. Drugs. 18:329-53 (1979). Barzilai N, Groop PH, Groop, DeFronzo RA. Acta Diabetol. 32:273-8 (1995). Lamensdorf I, He L, Nechushtan A et al. Eur J Pharmacol. 388:147-54 (2000).

Physical State :
Solid
Solubility :
Soluble in water (partly), chloroform, DMF, DMSO (48 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
200-203° C
Boiling Point :
689° C (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Cytochrome P450 3A4: IC50 = 7.45 µM (human)
pK Values :
pKa: 5.9, pKb: 1.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YS7640000
PubChem CID :
3478
Merck Index :
14: 4442
MDL Number :
MFCD00072159
EC Number :
249-427-6
Beilstein Registry :
0903495
SMILES :
CC1=NC=C(N=C1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Qi et al Qi et al. (PubMed ID 25294818) found that glipizide reduced endothelial cell migration and the formation of tubular structures, inhibiting angiogenesis by increasing natriuretic peptide receptor A expression in mice. -SCBT Publication Review
Date published: 2015-07-16
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