Glipizide is an ATP-dependent K+ channels blocker in pancreatic β cells and brain GABA containing neurons resulting in insulin release.
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine: D. Raeburn & T.J. Brown; J. Pharmacol. Exp. Ther. 256, 480 (1991) Quantitative autoradiography of the binding sites for [125I] iodoglyburide, a novel high-affinity ligand for ATP-sensitive potassium channels in rat brain: D.R. Gehlert, et al.; J. Pharmacol. Exp. Ther. 257, 901 (1991) Brogden RN, Heel RC, Pakes GE et al. Drugs. 18:329-53 (1979). Barzilai N, Groop PH, Groop, DeFronzo RA. Acta Diabetol. 32:273-8 (1995). Lamensdorf I, He L, Nechushtan A et al. Eur J Pharmacol. 388:147-54 (2000).
Soluble in water (partly), chloroform, DMF, DMSO (48 mg/ml), and methanol.
Store at room temperature
689° C (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.62 (Predicted)
Cytochrome P450 3A4: IC50 = 7.45 µM (human)
pKa: 5.9, pKb: 1.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Qi et alQi et al. (PubMed ID 25294818) found that glipizide reduced endothelial cell migration and the formation of tubular structures, inhibiting angiogenesis by increasing natriuretic peptide receptor A expression in mice. -SCBT Publication Review
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