Ginkgolide AA highly active PAF antagonist

Ginkgolide A (CAS 15291-75-5)

Ginkgolide A | CAS 15291-75-5 is rated 5.0 out of 5 by 1.
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Synonym: (1R,3R,8S,10R,13S,16S,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
Application: A highly active PAF antagonist
CAS Number: 15291-75-5
Purity: ≥98%
Molecular Weight: 408.40
Molecular Formula: C20H24O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree.


References

1. Braquet, P., et al. 1991. Med. Res. Rev. 11: 295-355. PMID: 1647474
2. Wada, K., et al. 1993. Biol. Pharm. Bull. 16: 210-212. PMID: 8364459

Physical State :
Solid
Solubility :
Soluble in water, acetone, ethanol, methanol, and DMSO.
Storage :
Store at -20° C
Melting Point :
255.65° C (Predicted)
Boiling Point :
710.06° C at 760 mmHg (Predicted)
Density :
1.57 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20/D 55.8°, c = 0.5 in ethanol
Ki Data :
GABA: Ki= 14.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KC9943000
PubChem CID :
441293
Merck Index :
14: 4426
MDL Number :
MFCD07437829
SMILES :
C[C@@H]1C(=O)O[C@@H]2[C@]1([C@@]34C(=O)O[C@H]5C3(C2)C6([C@@H](C5)C(C)(C)C)[C@H](O4)OC(=O)C6O)O

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Certificate of Analysis

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Ginkgolide A  Product Citations

See how others have used Ginkgolide A. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24475102  Chung, FH. et al. 2014. PLoS ONE. 9: e86299.

PMID: # 24044991  Lin, W. et al. 2013. Analytical biochemistry. 443: 252-60.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Chen et al Chen et al. (PubMed ID 22700047) found that ginkgolide activation of the PI3K-Akt signaling pathway may may prevent accumulation of p-Tau induced by okadaic acid and Tau hyperphosphorylation-related.toxicity. -SCBT Publication Review
Date published: 2015-06-27
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