Molecular structure of Ginkgolide A, CAS Number: 15291-75-5
Ginkgolide A (CAS 15291-75-5)
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Alternate Names:
(1R,3R,8S,10R,13S,16S,17R)-8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,18-trione
Application:
Ginkgolide A is a highly active PAF antagonist
CAS Number:
15291-75-5
Purity:
≥98%
Molecular Weight:
408.40
Molecular Formula:
C20H24O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ginkgolide A is a terpenoid compound that is a major constituent of Ginkgo biloba leaf extract. It has a unique terpene trilactone structure that has been widely studied for its role in biological systems. In research applications, Ginkgolide A is of considerable interest due to its contribution to the understanding of platelet-activating factor (PAF) receptor antagonism. As a natural PAF antagonist, Ginkgolide A is used in experiments to explore the cellular mechanisms of PAF in inflammation and related physiological processes. Additionally, it is of interest in neurobiology for its potential effects on neuronal protection and neurotransmission studies. Its involvement in modulating blood flow and neurotransmitter systems also makes it a compound of interest in cognitive and vascular research.
Ginkgolide A (CAS 15291-75-5) References
- Recent progress in ginkgolide research. | Braquet, P., et al. 1991. Med Res Rev. 11: 295-355. PMID: 1647474
- Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries. | Zhou, W., et al. 2006. J Vasc Surg. 44: 853-62. PMID: 17012008
- Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. | Rajaraman, G., et al. 2006. Toxicol Appl Pharmacol. 217: 225-33. PMID: 17045319
- Ginkgolide A reduces inflammatory response in high-glucose-stimulated human umbilical vein endothelial cells through STAT3-mediated pathway. | Zhao, Q., et al. 2015. Int Immunopharmacol. 25: 242-8. PMID: 25681539
- PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice. | Ye, N., et al. 2016. Biomol Ther (Seoul). 24: 40-8. PMID: 26759700
- Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. | Jeong, HS., et al. 2017. Biomed Pharmacother. 88: 625-634. PMID: 28142119
- Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons. | Kuo, LC., et al. 2019. J Agric Food Chem. 67: 81-89. PMID: 30541279
- Ginkgolide A protects adverse cardiac remodeling through enhancing antioxidation and nitric oxide utilization in mice with pressure overload. | You, W., et al. 2019. Pharmazie. 74: 698-702. PMID: 31739841
- Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis. | Mohandas, S. and Vairappan, B. 2020. Life Sci. 257: 118111. PMID: 32682918
- Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target. | Li, J., et al. 2021. Int Immunopharmacol. 95: 107514. PMID: 33677255
- Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation. | Zhao, K., et al. 2022. Eur J Pharmacol. 923: 174932. PMID: 35367419
- Ginkgolide A Participates in LPS-Induced PMVEC Injury by Regulating miR-224 and Inhibiting p21 in a Targeted Manner. | Liu, Z. and Yang, Y. 2022. Contrast Media Mol Imaging. 2022: 6384334. PMID: 36134118
- Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease. | Chen, WS., et al. 2023. Aging (Albany NY). 15: 1358-1370. PMID: 36863713
- Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy. | Wang, L., et al. 2023. Phytother Res.. PMID: 36932920
- Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. | Wada, K., et al. 1993. Biol Pharm Bull. 16: 210-2. PMID: 8364459
Inhibitor of:
PAF Acetylhydrolase, and Vmn2r72.Activator of:
CA VIII, LOXL1, Nrdp1, and PAF-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ginkgolide A, 10 mg | sc-205705 | 10 mg | $67.00 | |||
Ginkgolide A, 25 mg | sc-205705A | 25 mg | $159.00 | |||
Ginkgolide A, 250 mg | sc-205705B | 250 mg | $406.00 | |||
Ginkgolide A, 1 g | sc-205705D | 1 g | $1108.00 | |||
Ginkgolide A, 500 g | sc-205705C | 500 g | $679.00 |