GingerolAn apoptosis inducing, anti-oxidative and anti-inflammatory agent

Gingerol (CAS 23513-14-6)

Gingerol | CAS 23513-14-6 is rated 5.0 out of 5 by 1.
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Synonym: 6-Gingerol
Application: An apoptosis inducing, anti-oxidative and anti-inflammatory agent
CAS Number: 23513-14-6
Purity: ≥98%
Molecular Weight: 294.38
Molecular Formula: C17H26O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gingerol, a phenolic substance and a potent cardiotonic agent isolated from the rhizome of ginger, has been shown to stimulate the Ca2+-pumping activity of sarcoplasmic reticulum (SR) of rabbits in a concentration-dependent manner. It was noted that Gingerol specifically activated SERCA (Ca2+-ATPase of cardiac and skeletal SR). Additional research has shown Gingerol to inhibit platelet aggregation via suppression of thromboxane production. Gingerol blocked ATP release from platelets induced by adrenaline and adenosine 5-diphosphate and prevented secondary aggregation. It has been demonstrated that Gingerol contains antioxidant and antiinflammatory characteristics and could significantly inhibit 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis in mice. Furthermore, Gingerol has been noted as an agonist of the capsaicin-activated VR1 (vanilloid receptor) and in leukemia cell studies it has been shown to have apoptotic properties.


References

1. Kobayashi, M., et al. 1987. Biochim. Biophys. Acta. 903: 96-102. PMID: 2443170
2. Guh, J.H., et al. 1995. J. Pharm. Pharmacol. 47: 329-332. PMID: 7791032
3. Lee, E. and Surh,Y.J. 1998. Cancer Lett. 134: 163-168. PMID: 10025876
4. Dedov, V.N., et al. 2002. Br. J. Pharmacol. 137: 793-798. PMID: 12411409

Appearance :
Oil
Physical State :
Solid
Derived From :
<i>Zingiber Officinale Rosc</i>
Solubility :
Soluble in ethanol, benzene, ether, chloroform, methanol (1 mg/ml), and DMSO. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
20-25° C
Boiling Point :
~453.0° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.52
IC50 :
Ca2+-ATPase : EC5050 = 4 µM ( cardiac sarcoplasmic reticulum)
Ki Data :
Serotonin 1a (5-HT1a) receptor: Ki= >100 µM (human)
pK Values :
pKa: 10.02
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HE0757000
PubChem CID :
442793
Merck Index :
14: 4424
MDL Number :
MFCD00210507
SMILES :
CCCCC[C@@H](CC(=O)CCC1=CC(=C(C=C1)O)OC)O

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Gingerol  Product Citations

See how others have used Gingerol. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25813697  2015. Oncol. Rep. 33: 2331-6.

PMID: # 25231392  2014. Int. J. Mol. Med. 34: 1268-76.

PMID: # 23008012  2013. Phytother Res. 27: 1185-92.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Dedov et al Dedov et al. (PubMed ID 12411409) found that gingerol is an agonist of capsaicin-activated VR1 receptor 2 and evoked capsaicin-like calcium currents in cultured DRG neurons. -SCBT Publication Review
Date published: 2015-03-04
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