Gilvocarcin MThe minor analogue of Gilvocarcin V with anti-bact, -fungal, -viral and -tumor activity

Gilvocarcin M (CAS 77879-89-1)

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Application: The minor analogue of Gilvocarcin V with anti-bact, -fungal, -viral and -tumor activity
CAS Number: 77879-89-1
Purity: 95%
Molecular Weight: 482.5
Molecular Formula: C26H26O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from Streptomyces. Gilvocarcin M contains a methyl group in the 8-position and is less active than the vinyl analogue Gilvocarcin V (sc-202170), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones.


References

1. Nakano, H., et al. 1981. J. Antibiot. 34: 266-270. PMID: 7275807
2. Elespuru, R.K., et al. 1984. Science. 223: 69-71. PMID: 6229029
3. Oyola, R., et al. 1997. Photochem. Photobiol. 65: 802-810. PMID: 9155255
4. Balitz, D.M., et al. 1981. J. Antibiot. 34: 1544-1555. PMID: 7344705
5. Matsumoto, A., et al. 2000. Cancer Res. 60: 3921-3926. PMID: 10919670

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMF, DMSO, methanol (slightly), and 100% ethanol (slightly).
Storage :
Store at -20° C
Melting Point :
319.72° C (Predicted)
Boiling Point :
794.64° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DI2250000
PubChem CID :
53801
Beilstein Registry :
5675008
SMILES :
CC1C(C(C(C(O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=CC(=CC(=C54)OC)C)OC)O)O)O

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Certificate of Analysis

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