GGACKA potent and irreversible inhibitor of uPA and factor Xa

GGACK (CAS 65113-67-9)

GGACK | CAS 65113-67-9 is rated 5.0 out of 5 by 1.
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Synonym: Glutamyl-glycyl-arginine chloromethyl ketone
Application: A potent and irreversible inhibitor of uPA and factor Xa
CAS Number: 65113-67-9
Molecular Weight: 466
Molecular Formula: C14H25ClN6O52HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

GGACK is a specific and potent Factor X (factor Xa) inhibitor, reported to decrease creatine kinase and amylase activity. Reports indicate that GGACK strongly inhibits uPA (urokinase)-induced plasmin generation and acts as an anticoagulant. GGACK is an inhibitor of Factor IX, Factor VII and Trypsin.


References

1. Oethinger, M.D. and Seifried, E. 1990. Thromb. Haemost. 64: 402-406. PMID: 1710833
2. Ge, M., et al. 1992. J. Clin. Invest. 90: 2508-2516. PMID: 1281836
3. Kebabian, P.R. and Henkin, J. 1992. Thromb. Res. 65: 401-407. PMID: 1631804
4. Lyon, M.E., et al. 1999. Clin. Chim. Acta. 280: 91-99. PMID: 10090527

Physical State :
Solid
Sequence :
H-Glu-Gly-Arg-chloromethylketone
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
340.38° C
Density :
1.52 g/cm3
Refractive Index :
n20D 1.62
IC50 :
urokinase: IC50 = <1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3080903
SMILES :
C(CC(C(=O)CCl)NCC(=O)NC(=O)C(CCC(=O)O)N)CN=C(N)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Lyon et al Lyon et al. (PubMed ID 10090527) found that the protease inhibitor, GGACK, showed anticoagulative effects resulting from the decrease creatine kinase and amylase activity. -SCBT Publication Review
Date published: 2015-05-22
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